Our dismutase mimetics are designed to convert the bursts of superoxide induced by radiotherapy to hydrogen peroxide. As a result, in various nonclinical experiments they significantly reduce the immediate and long-term radiation damage to normal tissue in a variety of organs.1,2
1. Thompson JS, Chu Y, Glass J, Tapp AA, Brown SA. The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation. Free Radic Res. 2010;44(5):529-540.
2. Coleman MC, Olivier AK, Jacobus JA, et al. Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3. Antioxid Redox Signal. 2014;20(9):1423-1435.