Transforming radiotherapy

Our small-molecule dismutase mimetics are designed to increase the rapid conversion of superoxide to hydrogen peroxide, which may be key to reducing treatment-related side effects and increasing the anti-cancer efficacy of these treatments.

Dismutase mimetics convert superoxide to hydrogen peroxide and molecular oxygen. The metabolic processing of superoxide is a critical cellular function and part of the broader oxygen metabolic pathways that keep cells functioning. While oxygen metabolic pathways are involved in a host of diseases, Galera is focused on changing how radiotherapy is used in cancer patients to both reduce the side effects of radiation therapy and enhance the therapeutic effect.