Pipeline

Tilarginine is L-NMMA (NG-monomethyl-L-arginine), a nitric oxide synthase (NOS) inhibitor, administered IV over 2 hours, with Amlodipine pretreatment
TNBC = Triple-negative Breast Cancer, PI3Ki = Inhibitor of Phosphoinositide 3-kinase. Nab-paclitaxel = nanoparticle albumin-bound paclitaxel (Abraxane)
HMRI = Houston Methodist Research Institute; NCI=National Cancer Inst.; I-SPY 2 = Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis 2